The whole set of slides can be directly downloaded HERE
Day 1 – Tuesday, 21st May 2019
13:30 – 14:00 Registration & Welcome coffee
14:00 – 18:00 Course: How to practically implement adaptive design? (SLIDES)
Adrian Mander and James Wason, MRC Biostatistics Unit, University of Cambridge
Including coffee break (15:45 – 16:15)
Day 2 – Wednesday, 22nd May 2019
08:00 – 08:40 Registration continued
08:40 – 09:00 Welcome to the main conference
Session 1 Session Theme: Decision making in digitalized world
Chair: Emmanuel Lesaffre
09:00 – 09:45 Invited talk: Prof. Kerrie Mengersen, Queensland University of Technology, Australia (SLIDES)
Bayesian Learning for Decision Making in the Big Data Era
09:45 – 10:05 Marmaduke Woodman (University of Aix-Marseille) (SLIDES)
Translational Neuroscience: from dynamical systems to personalized medicine
10:05 – 10:25 Pantelis Samartsidi (University of Cambridge) (SLIDES)
A Bayesian multivariate factor analysis model for evaluating an intervention using observational time-series data on multiple outcomes
10:25 – 10:45 Yingbo Wang (Novartis Pharma AG) (SLIDES)
Bayesian non-inferiority design borrowing strength from historical controls with a meta-analytic-predictive approach
10:45 – 11:15 Coffee Break & Sweeties
11:15 – 11:35 Alice Gosselin (Sanofi) (SLIDES)
Comparison Study for Matching Methodologies for Historical Data Borrowing
11:35 – 11:55 Marta Pittavino (University of Geneva) (SLIDES)
A Bayesian hierarchical model to integrate dietary exposure and biomarker measurements for the risk of cancer
11:55 – 12:05 180 seconds challenge:
- Moran (University of Adelaide, Australia)
Evidence Synthesis: a comparison of Bayesian and frequentist approaches
- Noel Cressie (University of Wollongong – Australia) (SLIDES)
Bayesian forecasting of infectious diseases with SIRS models
12:05 – 13:30 Lunch time
13:30 – 13:40 Serious Game
Session 2 Session Theme: Bayesian modeling
Chair: Laurent Estève
13:40 – 14:25 Invited talk: Prof. Jean-Michel Marin, University of Montpellier (SLIDES)
Bayesian model choice
14:25 – 14:45 Amy Shi (SLIDES)
Introducing the BGLIMM Procedure for Bayesian Generalized Linear Mixed Models
14:45 – 15:05 Sophie Ancelet (Institut de Radioprotection et de Sûreté Nucléaire, Paris)
A Bayesian Poisson mixture model for model selection and dose estimation in biological retrospective dosimetry
15:05– 15:25 Haitao Chu (University of Minnesota) (SLIDES)
A Bayesian Hierarchical Model Estimating CACE in Meta-analysis of Randomized Clinical Trials with Noncompliance
15:25 – 15:55 Coffee Break
Session 3 Session Theme: Non-linear modeling
Chair: Astrid Jullion
15:55 – 16:40 Invited talk: Dr. François Mercier, Roche (SLIDES)
Bayesian non-linear disease progression models
16:40 – 17:00 Antoine Pissoort (Pharmalex) (SLIDES)
A Bayesian Disease progression model of Parkinson Disease combining RWD and natural history data to evaluate a new treatement
17:00 – 17:20 Maud Hennion (Pharmalex) (SLIDES)
Pharmacokinetic Model with SAS – Proc MCMC with applications to preclinical pharmacology
17:20 – 17:40 Fabiola La Gamba (Janssen Pharmaceutica) (SLIDES)
Bayesian sequential integration within a preclinical PK/PD modeling framework: Lessons learned
17:40 – 17:50 Day 2 closure & Social event details
19:30 – 23:00 Social Event
Day 3 – Thursday, 23rd May 2019
08:00 – 08:20 Registration continued
08:20 – 08:30 Welcome to Day 3
Session 4 Session Theme: Designing clinical trials
Chair: Heinz Schmidli
08:30 – 09:15 Invited talk: Dr. Kaspar Rufibach, Roche (SLIDES)
Bayesian Predictive Power: Theory, challenges in implementations and perspectives
09:15 – 09:35 Arnaud Monseur (Pharmalex) (SLIDES)
From Power and Assurance to Bayesian Power: application to probability of success
09:35 – 09:55 Astrid Jullion (Novartis) (SLIDES)
Probability of success: a viable concept to inform the early development of a topical drug
09:55 – 10:15 Samuel Pawel (University of Zurich) (SLIDES)
Predictive Evaluation of Replication Studies
10:15 – 10:45 Coffee Break & Sweeties
10:45 – 11:05 Charlotte Micheloud (University of Zurich) (SLIDES)
Sample Size Calculation for Replication Studies
11:05 – 11:25 Annette Kopp-Schneider (German Cancer Research Center) (SLIDES)
Use of external information in clinical trials: What can be gained in terms of frequentist power?
11:25 – 12:10 Invited talk: Prof. Dr. Eric-Jan Wagenmakers, Amsterdam University, NL
Bayesian benefits for the pragmatic biostatistician (SLIDES)
12:10 – 13:25 Lunch time
13:25 – 13:35 Serious Game
Session 5 Session Theme: Inference in clinical research
Chair: Bruno Boulanger
13:35 – 13:55 180 seconds challenge
- Sylvia Calderazzo (German cancer research center) (SLIDES)
Bayesian clinical trials design and evaluation: a decision-theoretic view
- Maha Alsefri (University of Liverpool) (SLIDES)
Bayesian joint modelling of longitudinal and time to event data: A review of methods and issues
- Audrey Larue-Triolet (BioMérieux) (SLIDES)
Bayesian method to predict the probability to comply to the criteria for a future study or to monitor a new study
13:55 – 14:40 Invited talk: Prof. Sara Geneletti, London School of Economics, UK
Causal inference in clinical research (SLIDES)
14:40 – 15:00 Burak Kürsad Günhan (University Medical Center Göttingen) (SLIDES)
Model-based meta-analysis using arm-based models
15:00 – 15:20 Jing Zhang (University of Maryland)
Bayesian joint meta-regression methods adjusting for post-randomization variables in network meta-analysis?
15:20 – 15:40 Kelly R. Moran (Duke University) (SLIDES)
Bayesian hierarchical factor regression models to infer cause of death from verbal autopsy data
15:40 – 16:10 Coffee Break & Sweeties
Session 6 Session Theme: Bayesian Statistics in CMC
Chair: Didier Poirault
16:10 – 16:55 Invited talk: Dr. Mike Denham, GSK, UK:
Bayesian Statistics in CMC (SLIDES)
16:55 – 17:15 Piotr Juszczak (Roche Diagnostics)
On supporting development of diagnostic assays with Bayesian modelling and simulation
17:15 – 17:35 Bernard G Francq (GSK Vaccines) (SLIDES)
Bayesian Coefficients of Variation in Linear Mixed Models, Random Effects and Precision in Assay Qualification
17:35 – 17:55 Xiaolong Luo (Celgene Corporation) (SLIDES)
Comparison of Bayesian Multivariate Models for Detecting Safety Signals in Clinical Trials
17:55 BAYES2020 Announcement
Day 4 – Friday, 24th May 2019
08:00 – 08:20 Registration continued
08:20 – 08:30 Welcome to Day 4
Session 7 Session Theme: Bayesian statistics for 21st century cures
Chair: Leonhard HELD
08:30 – 09:10 J. Jack Lee, Ying Yuan, Department of Biostatistics, University of Texas MD Anderson Cancer Center (SLIDES)
Bayesian Model-Assisted Designs and Their Applications for Early Phase Clinical Trials – When Simplicity Meets Superiority
09:10 – 09:30 Forrest Williamson (Eli Lilly and Company) (SLIDES)
Bayesian applications in rare disease clinical trial research
09:30 – 09:50 Barbara Wendelberger (Berry Consultants, USA) (SLIDES)
Guiding clinical trial design for a rare disease using natural history data and Bayesian disease progression modeling
09:50 – 10:10 Angély Loubert (Université de Lyon) (SLIDES)
Combination of prior distributions elicited from expert opinions previous to Bayesian inference. Application to personalized medicine
10:10 – 10:40 Coffee Break & Sweeties
10:40 – 11:00 Pierre Colin (Sanofi) (SLIDES)
Use of Probability of Success – A way to manage more available information
11:00 – 11:20 Anna Pöhlmann (University of Bamberg, Germany) (SLIDES)
An R Shiny App to design and analyse basket trials in Oncology
11:20 – 11:40 Oliver Sailer (Boehringer Ingelheim) (SLIDES)
Exploring early interim analyses in basket designs in Oncology
11:40 – 12:00 Haiyan Zheng (Newcastle University) (SLIDES)
Bayesian basket trial designs for borrowing of information across similar subpopulations
12:00 – 12:15 Closing Event & lunch
